As a physician with over 25 years in internal medicine, I spend a lot of time talking with women who feel off. Low energy, stubborn bloating, mood swings, irregular cycles, or the sense that their bodies aren’t responding the way they used to.
What I see most often isn’t a lack of effort. It’s a lack of key micronutrients. Modern diets, stress, ultra-processed foods, and reliance on synthetic vitamins leave many women under-nourished in iron, B vitamins, zinc, folate, and vitamin A—nutrients that play foundational roles in hormone rhythms, energy production, and overall vitality.
I don’t recommend the same supplement to every patient. Needs vary by age, lifestyle, and tolerance. Over the years, I’ve spent countless hours reviewing ingredient labels, lab results, and patient feedback—often so my patients don’t have to. The supplements below are the ones women ask me about most often, and how I think about them in practice.
1. Primal Queen
Primal Queen is the supplement I recommend most often because it addresses a core issue I see repeatedly: women are missing bioavailable micronutrients, not just “more vitamins.”
Unlike synthetic multivitamins or powders, Primal Queen is made from six grass-fed beef organs, including uterus, ovaries, and fallopian tubes, alongside liver, heart, and kidney. These organs naturally provide heme iron, retinol (true vitamin A), B12, natural folate, zinc, selenium, CoQ10, amino acids, and their built-in co-factors, which help the body actually use what it’s given.
From a clinical perspective, this matters. Heme iron absorbs better than plant iron. Retinol is more usable than beta-carotene. Natural folate behaves differently than folic acid. When nutrients arrive in their food matrix, patients often report steadier energy, calmer cravings, improved skin, and more predictable cycles over time.
It’s also simple: two peppermint-scented capsules daily, no taste, no prep. Not a hormone “hack, ”just foundational nourishment that supports how the body works.
That said, this isn’t a shortcut. Primal Queen won’t compensate for a consistently poor diet or chronic under-eating, and it’s not a fit for women who prefer plant-only supplements. As with any whole-food approach, results depend on consistency and should be viewed as part of a broader nutrition and lifestyle foundation.
2. Mother’s Best Liver Pills
A liver-based supplement can be a smart “starter” option for women who know they need more nutrient density but aren’t ready to overhaul everything. Beef liver naturally contains vitamin A, iron, and B12. These three nutrients are often correlated with energy, skin clarity, and overall vitality support.
Where liver-only products tend to fall short is breadth. They’re focused on one organ, so you’re not getting the complementary nutrients from heart and kidney (like CoQ10 and selenium support), and you’re also missing female-specific organs that many women prefer when the goal is cycle and hormone rhythm support. In other words: it can help, but it’s not as comprehensive as a multi-organ, female-first formula.
3. Drugstore Multivitamins
Drugstore multis win on one thing: accessibility. They’re easy to find, easy to afford, and better than taking nothing if someone’s diet is inconsistent.
The drawback is that many rely on isolated, lab-made nutrients (like non-heme iron or folic acid) and may include forms that aren’t ideal for every woman, especially those with sensitive stomachs. They also typically don’t offer the “food matrix” co-factors that help the body utilize nutrients efficiently. In practice, I often see women taking a multivitamin faithfully and still wondering why their energy and mood aren’t budging.
4. Thorne Hormone Advantage
Thorne is a reputable brand and tends to be thoughtful about formulation quality, which is a genuine win in a crowded category. Products like Hormone Advantage are typically designed around botanical or targeted ingredients that can be useful for how you feel, especially when stress is high or symptoms feel cyclical.
The limitation is that this approach is often symptom-facing, not foundational. Herbal blends may support stress response and mood, but they don’t replace missing iron, B12, zinc, folate, or vitamin A. In my experience, many women feel a short-term lift and then plateau if underlying micronutrient gaps aren’t addressed alongside it.
5. AG1 Greens Powder
Greens powders can be an easy way to build a consistent wellness habit, and many women like them for digestion support and “getting something in” on busy mornings. If someone struggles with fiber intake, a greens-style product can be a helpful nudge.
But greens powders usually aren’t designed to deliver the specific micronutrients women commonly miss, particularly iron, B12, retinol (true vitamin A), and zinc. They can complement a routine, but they rarely move the needle for energy, mood steadiness, or cycle-related concerns the way a nutrient-dense, whole-food formula can.
Final Takeaway
When women feel depleted, piling on stimulants or symptom-focused products rarely helps long-term. The body needs raw materials first.
That’s why after reviewing many products I find that Primal Queen stands out. It focuses on replenishing the nutrients women are most often missing—using whole-food sources the body recognizes—rather than masking symptoms.
If you’ve been “doing everything right” and still feel stuck, nourishment—not willpower—may be the missing piece.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
